Intervertebral disc degeneration (IDD) is a major cause of chronic and debilitating back pain whose prevalence and severity make it a major health issue of substantial socioeconomic importance. Abstracts from the Scoliosis Research Society. Le laboratoire Médecine Régénératrice et Squelette (RMeS - UMR 1229 Inserm Université de Nantes) a publié un article dans la revue "Biomaterials" qui présente une perspective prometteuse pour la régénération des disques intervertébraux et d’une manière générale pour la prise en charge des patients atteints de lombalgie d’origine discal. 23 This suggests that nucleus pulposus is exempt from prior exposure to the … Biomaterials for regeneration of the intervertebral disc must meet complex requirements conforming to biological, mechanical and clinical demands. Stem cell therapies offer huge potential to revolutionize the treatment of cartilage defects, disc herniations, and disc degeneration. [Regeneration strategies of intervertebral disc]. Growth factors, gene therapy, stem cell transplantation and biomaterials‐based tissue engineering might support intervertebral disc regeneration by overcoming the limitation of the self‐renewal mechanism. Early research attempting to characterize the intervertebral disc demonstrated an immune response when subjects were exposed to their own nucleus pulposus tissue. Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres Tissue Eng. Low back pain is a disorder that affects a considerable proportion of the population About 60–80% of all people suffer from back pain at some time during their life Degeneration of the intervertebral disc (IVD) and disc herniation are two distinct but … 1: 983-989. Intervertebral Disc Medicine & Life Sciences. Pauline Colombier 1 Anne Camus 2 Laurent Lescaudron 1 Johann Clouet 3 Jérôme Guicheux 1 Détails. Retrouvez Intervertebral Disc Regeneration Using Mesenchymal Stem Cells: A Mouse Model Study et des millions de livres en stock sur Amazon.fr. Together they form a unique fingerprint. A GLIMPSE OF THE NOVEL INTERVENTIONAL APPROACHES Babak Ashrafnejad MD Pain Fellowship Anesthesiologist 2. Intervertebral disc regeneration: do nutrients lead the way? Intervertebral disc regeneration: influence of growth factors on differentiation of human mesenchymal stem cells (hMSC). The IVD is composed of a gelatinous nucleus pulposus (NP) centre and several surrounding coaxial lamellae that form the inner and outer anulus fibrosus. Intervertebral disc degeneration is a concept for which in medicine, up to the present time, there is no widely agreed definition. Cell- and Tissue-Based Therapy Medicine & Life Sciences. There is degeneration of the nucleus pulposus and extrusion/prolapse of disc material dorsally, causing compression of the spinal cord. Recent advances in our understanding of intervertebral disc biology led to an increased interest in the development of novel biological treatments aimed at disc regeneration. Growing a backbone – functional biomaterials and structures for intervertebral disc (IVD) repair and regeneration: challenges, innovations, and future directions . Approximately 50–70% of patients who underwent sequestrectomy after experiencing a disc herniation still report of back pain [23, 25]. Achetez neuf ou d'occasion Regeneration of the intervertebral disc. OBJECTIVE: To review the research progress of the seed cells, scaffolds, growth factors, and the prospects for clinical application of the intervertebral disc regeneration. The Future of Spinal Disc Regeneration. Intervertebral disc regeneration: a great challenge for tissue engineers . 2007 Jan;13(1):147-58. doi: 10.1089/ten.2006.0042. 5 Herein, we will discuss the prevalence of and risk factors for IDD, structure of intervertebral disc (IVD), pathomechanism and histological features of IDD, and IVD progenitors. Cheug KMC, Ho G, Chan D (2004) Intervertebral Disc Regeneration by Use of Autologous Mesenchymal Stem Cells, an Experimental Model in Rabbits. Fingerprint Dive into the research topics of 'Stem cell therapy for intervertebral disk regeneration'. Abstract. Intervertebral disc (IVD) degeneration is associated with most cases of cervical and lumbar spine pathologies, amongst which chronic low back pain has become the number one cause of loss of quality-adjusted life years. Med J Aust. The treatment with the cell-derived matrix solution would restore the natural rhythm of hydration of a natural disc as well. Regeneration Medicine & Life Sciences. The intervertebral disc (IVD) is a fibrocartilaginous tissue composed of a peripheral network of robust collagen fibers, termed the annulus fibrosus, which surrounds a hydrated gel-like central structure known as the nucleus pulposus (NP), and the inferior and superior cartilaginous endplates which provide the connection to the vertebral body. The avascularity of the intervertebral disc, although certainly limiting its potential for repair and regeneration, does confer a significant advantage. Strategies to repair damaged intervertebral discs rely on the premise that these structures can be regenerated using cellular-based approaches. Herein, it is reviewed the state-of-the-art of intervertebral disc regeneration strategies from the perspective of cells, scaffolds, or constructs, including both popular and unique tissue engineering approaches. Ehlicke F(1), Freimark D, Heil B, Dorresteijn A, Czermak P. Author information: (1)Institute of Biopharmaceutical Technology, University of Applied Sciences Giessen-Friedberg, Giessen - Germany. Degeneration of intervertebral disc (IVD) is the main cause of neck and low back pain. Bone, Intervertebral disc - Degeneration in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). Currently no consensus on their characterization exists. DOI: 10.22203/eCM.v030a15 ISSN 1473-2262. Crock HV (1970) A reappraisal of intervertebral disc lesions. Intervertebral disc degeneration (IDD) is a major contributor to LBP, 4 and it also precedes other spinal disorders such as disc herniation, spondylosis, and lumbar spinal stenosis. Clinical Translation. In intervertebral disc bulge, the circumference of disc extends beyond the vertebral bodies. Author information: (1)Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China. Dr. Chahine’s research looks at degeneration and regeneration of the intervertebral disc, applying tools of bioengineering, cell and tissue biomechanics, and animal physiology to study the function of the disc and disc cells, emphasizing degradation processes and inflammation. Disc regeneration 1. inflammation, regeneration, intervertebral disc homeostasis Author for correspondence: Ma´rio A. Barbosa e-mail: mbarbosa@ineb.up.pt Inflammation in intervertebral disc degeneration and regeneration Maria Molinos1,2, Catarina R. Almeida1, Joana Caldeira1,3, Carla Cunha1, Raquel M. Gonc¸alves1 and Ma´rio A. Barbosa1,2 1Instituto de Engenharia Biome ´dica—INEB, 2Instituto de … Enhancing intervertebral disc repair and regeneration through biology: platelet-rich plasma as an alternative strategy Shan-Zheng Wang1 †, Yun-Feng Rui1*†, Qi Tan2 and Chen Wang1* Abstract Intervertebral disc degeneration (IDD) is a common orthopedic disease associated with mechanical changes that may result in significant pain. Strategies to target and modulate inflammation towards intervertebral disc regeneration. The EuroDISC clinical trial investigated the transplantation of expanded autologous disc chondrocytes in patients undergoing single level discectomy. 4.1. Review Article A Review of Animal Models of Intervertebral Disc Degeneration: Pathophysiology, Regeneration, and Translation to the Clinic ChrisDaly, 1,2,3 PeterGhosh, 1,4 GrahamJenkin, 1 DavidOehme, 1,5 andTonyGoldschlager 1,2,3 e Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC , Australia Degeneration of the intervertebral discs (IVD) of the spinal column represents a major challenge for successful biological and tissue-engineered treatments. Noté /5. Biomaterials for intervertebral disc regeneration. Osti OL, Vernon-Roberts B, Moore R, Fraser RD (1992) Annular tears and disc degeneration in the lumbar … Collagen Type II Medicine & Life Sciences. INTERVERTEBRAL DISK DEGENERATION AND REGENERATION (MV RISBUD, SECTION EDITOR) Intervertebral Disc Biology: Genetic Basis of Disc Degeneration Sabrina Munir1 & Marinko Rade2,3 & Juhani H. Määtt ä1,4 & Maxim B. Freidin1 & Frances M. K. Williams1 Published online: 3 August 2018 # The Author(s) 2018 Abstract Purpose of Review This review aims to highlight recent advances in … A intervertebral disc herniation involves the nucleus pulposus. 1 Université de Nantes - UFR Odontologie . The prevalence of chronic disabling back pain has tripled over the last 20 years [1] and the treatment of lower back pain in the United States is estimated to cost more than $100 billion per year. The three cell types detailed are notable for having demonstrated the ability to promote intervertebral disc regeneration in preclinical trials with subsequent progression to clinical trials/series. The researchers concluded that stem cell therapy might be useful for intervertebral disc regeneration. Promoting IVD regeneration relies on restoring naive IVD properties by: (i) recovering IVD biomechanics, (ii) re-establishing cell biological activity, including production of healthy ECM, and (iii) reducing IVD-associated pain. 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